Research Grants
With the support of our SDS families and generous supporters, Shwachman Diamond Syndrome Foundation has funded the following projects in the United States and other countries. SDS is a very rare disease, we are grateful to those researchers who are willing to give their time and expertise to help those living with SDS.
If you are a researcher interested in submitting a grant request, please email info@shwachman-diamond.org.
| Year | Principal Investigator | Project Title |
| 2023 | Akiko Shimamura, MD, PhD | Improving Surveillance for leukemia risk in SDS |
| 2022 | Professor Alan Warren | SDS Drug Discovery |
| 2020 | Garry Tobin, MD | Diabetes Study |
| 2016 | Marc Raaijmakers,MD, PhD Erasmus Medical Center, Netherlands |
“Reconstructing” Leukemogenesis in Shwachman Diamond Syndrome |
| 2016 | Seth Corey, MD | Identification of Cooperating Genes in the Transformation of SDS to MDS/ AML in the Zebrafish Model that Phenocopies Human SDS |
| 2015 | Seth Corey, MD | Identification of Cooperating Genes in the Transformation of SDS to MDS/ AML in the Zebrafish Model that Phenocopies Human SDS |
| 2015 | Allison Bertuch, MD, PhD | Why are Shwachman-Diamond Syndrome Cells Hypersensitive to y-irradiation? |
| 2014 | Johnson Liu, MD | SBDS Gene Expression Levels and Hematopoietic Defect in Shwachman-Diamond Syndrome: Groundwork and Application for Gene Therapy |
| 2011 | Paul de Figueiredo, PhD and Akiko Shimamura, MD, PhD | Drug screen to show that HDAC (histone deacetylase) inhibitors will improve growth of Sdo1 deficient yeast cells |
| 2010 | Paul de Figueiredo, PhD | Small molecule therapeutic approaches to SDS |
| 2008 | Akiko Shimamura, MD, PhD Fred Hutchinson Cancer Research Center |
North American Shwachman-Diamond Syndrome Registry |
| 2008 | Nicholas Trede, MD University of Utah |
Genetic analysis of Ceylon, a Zebrafish mutant with a genetically heritable SDS-like birth defect |
| 2007 | Akiko Shimamura, MD, PhD | The Human SDS protein, SBDS, associates with Ribosomal RNA |
| 2006 | David Pearce, MD University of Rochester |
Functional characteristics of sdo1p/SBDS |
| 2006 | E. Nicolis, MD University Hospital of Vernon, Verona, Italy |
SBDS mRNA expression in peripheral blood leukocytes |
| 2006 | Peter Durle, MD Hospital for Sick Children and University of Toronto |
SBDS protein expression in peripheral blood leukocytes |
| 2005 | Yigal Dror, MD Hospital for Sick Children and University of Toronto |
Identification of Genes involved in Marrow Failure and Malignant Myeloid Transformation by Gene Expression Analysis of Bone Marrows from Patients with Shwachman-Diamond syndrome and other inherited Marrow Failure Syndromes |
| 2004 | Johnson Liu, MD Mount Sini School of Medicine |
Hematopoietic Defect in Shwachman-Diamond Syndrome Knockdown and Overexpression of SBDS. |
E-mail info@shwachman-diamond.org if interested in applying for a research grant.
